MovDisordV3, Main, Exploration, bibRecord, 003906

Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra

Identifieur interne : 003906 ( Main/Exploration ); précédent : 003905; suivant : 003907

Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra

Auteurs : Maher A. Noureddine [États-Unis] ; Yi-Ju Li [États-Unis] ; Joelle M. Van Der Walt [États-Unis] ; Robert Walters [États-Unis] ; Rita M. Jewett [États-Unis] ; Hong Xu [États-Unis] ; Tianyuan Wang [États-Unis] ; Jeffrey W. Walter [États-Unis] ; Burton L. Scott [États-Unis] ; Christine Hulette [États-Unis] ; Don Schmechel [États-Unis] ; Judith E. Stenger [États-Unis] ; Fred Dietrich [États-Unis] ; Jeffery M. Vance [États-Unis] ; Michael A. Hauser [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2005-10.

RBID : ISTEX:5074B50F5F664B19062B337DCDC8A5C8366CC5B0

Descripteurs français

Pascal (Inist)
- Convergence, Liaison génétique, Locus niger, Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Convergence, DNA, Mitochondrial (genetics), Expressed Sequence Tags (metabolism), Female, Gene Expression, Gene Library, Genetic Linkage (genetics), Genetic Predisposition to Disease, Genetic Techniques, Genetic linkage, Humans, Locus niger, Male, Nervous system diseases, Oligonucleotide Array Sequence Analysis (methods), Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Proteomics (methods), RNA, Messenger (genetics), RNA, Messenger (metabolism), Risk Factors, Substantia Nigra (metabolism), Substantia Nigra (pathology), genomic convergence, linkage.
MESH :
- chemical , genetics : DNA, Mitochondrial, RNA, Messenger.
- genetics : Genetic Linkage, Parkinson Disease.
- metabolism : Expressed Sequence Tags, Parkinson Disease, RNA, Messenger, Substantia Nigra.
- methods : Oligonucleotide Array Sequence Analysis, Proteomics.
- pathology : Parkinson Disease, Substantia Nigra.
- Aged, Aged, 80 and over, Female, Gene Expression, Gene Library, Genetic Predisposition to Disease, Genetic Techniques, Humans, Male, Risk Factors.

Abstract

Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/5074B50F5F664B19062B337DCDC8A5C8366CC5B0/fulltext/pdf

DOI: 10.1002/mds.20573

Affiliations:

Le document en format XML

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<term>Expressed Sequence Tags (metabolism)</term>
<term>Female</term>
<term>Gene Expression</term>
<term>Gene Library</term>
<term>Genetic Linkage (genetics)</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Techniques</term>
<term>Genetic linkage</term>
<term>Humans</term>
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<term>Substantia Nigra (metabolism)</term>
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<front><div type="abstract" xml:lang="fr">Genomic convergence is a multistep approach that combines gene expression with genomic linkage to identify and prioritize susceptibility genes for complex disease. As a first step, we previously performed linkage analysis on 174 multiplex Parkinson's disease (PD) families, identifying five peaks for PD risk and two for genes affecting age at onset (AAO) in PD [Hauser et al., Hum Mol Genet 2003;12:671–677]. We report here the next step: serial analysis of gene expression [SAGE; Scott et al., JAMA 2001;286:2239–2242] to analyze substantia nigra tissue from three PD patients and two age‐matched controls. We find 933 differentially expressed genes (P < 0.05) between PD and controls, but of these, only 50 genes represented by unique SAGE tags map within our previously described PD linkage regions. Furthermore, genes encoded by mitochondrial DNA are expressed 1.5‐fold higher in PD patients versus controls, without an increase in the corresponding nuclear‐encoded mitochondrial components, suggesting an increase in mtDNA genomes in PD or a disjunction with nuclear expression. The next step in the genomic convergence process will be to screen these 50 high‐quality candidate genes for association with PD risk susceptibility and genetic effects on AAO. © 2005 Movement Disorder Society</div>
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<name sortKey="Jewett, Rita M" sort="Jewett, Rita M" uniqKey="Jewett R" first="Rita M." last="Jewett">Rita M. Jewett</name>
<name sortKey="Li, Yi U" sort="Li, Yi U" uniqKey="Li Y" first="Yi-Ju" last="Li">Yi-Ju Li</name>
<name sortKey="Li, Yi U" sort="Li, Yi U" uniqKey="Li Y" first="Yi-Ju" last="Li">Yi-Ju Li</name>
<name sortKey="Noureddine, Maher A" sort="Noureddine, Maher A" uniqKey="Noureddine M" first="Maher A." last="Noureddine">Maher A. Noureddine</name>
<name sortKey="Schmechel, Don" sort="Schmechel, Don" uniqKey="Schmechel D" first="Don" last="Schmechel">Don Schmechel</name>
<name sortKey="Schmechel, Don" sort="Schmechel, Don" uniqKey="Schmechel D" first="Don" last="Schmechel">Don Schmechel</name>
<name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton L." last="Scott">Burton L. Scott</name>
<name sortKey="Scott, Burton L" sort="Scott, Burton L" uniqKey="Scott B" first="Burton L." last="Scott">Burton L. Scott</name>
<name sortKey="Stenger, Judith E" sort="Stenger, Judith E" uniqKey="Stenger J" first="Judith E." last="Stenger">Judith E. Stenger</name>
<name sortKey="Van Der Walt, Joelle M" sort="Van Der Walt, Joelle M" uniqKey="Van Der Walt J" first="Joelle M." last="Van Der Walt">Joelle M. Van Der Walt</name>
<name sortKey="Van Der Walt, Joelle M" sort="Van Der Walt, Joelle M" uniqKey="Van Der Walt J" first="Joelle M." last="Van Der Walt">Joelle M. Van Der Walt</name>
<name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M." last="Vance">Jeffery M. Vance</name>
<name sortKey="Vance, Jeffery M" sort="Vance, Jeffery M" uniqKey="Vance J" first="Jeffery M." last="Vance">Jeffery M. Vance</name>
<name sortKey="Walter, Jeffrey W" sort="Walter, Jeffrey W" uniqKey="Walter J" first="Jeffrey W." last="Walter">Jeffrey W. Walter</name>
<name sortKey="Walter, Jeffrey W" sort="Walter, Jeffrey W" uniqKey="Walter J" first="Jeffrey W." last="Walter">Jeffrey W. Walter</name>
<name sortKey="Walters, Robert" sort="Walters, Robert" uniqKey="Walters R" first="Robert" last="Walters">Robert Walters</name>
<name sortKey="Walters, Robert" sort="Walters, Robert" uniqKey="Walters R" first="Robert" last="Walters">Robert Walters</name>
<name sortKey="Wang, Tianyuan" sort="Wang, Tianyuan" uniqKey="Wang T" first="Tianyuan" last="Wang">Tianyuan Wang</name>
<name sortKey="Wang, Tianyuan" sort="Wang, Tianyuan" uniqKey="Wang T" first="Tianyuan" last="Wang">Tianyuan Wang</name>
<name sortKey="Xu, Hong" sort="Xu, Hong" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
</country>
</tree>
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</record>

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Movement Disorders (revue)

Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra

Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra

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	Movement Disorders (revue)
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